Improving carvacrol bioaccessibility using core–shell carrier-systems under simulated gastrointestinal digestion

• Core-shell carrier systems were developed via layer-by-layer assembly to deliver carvacrol. Particle size and charge of the core–shell carriers greatly influenced by BSA coatings. exhibited better stability under simulated digestion conditions. Chitosan/BSA improved sustained release bioaccessibility The impact encapsulating carvacrol in chitosan-albumin based nano-carriers (NCs) on its was determined These NCs consisted chitosan (C) core enclosed bovine serum albumin (BSA) shell. mean particle ranged from 52.4 ± 10 nm 203 6 zeta-potential + 21 3.6 ?18 2.7 mV. significantly modified after protein-shell formation around polysaccharide-core. more stable, with less aggregation gastrointestinal conditions than C-NCs, presumably due greater steric repulsion. Likewise, observed relatively stabilized intestinal phase gastric phase. enhanced when it encapsulated NCs. findings imply that C-BSA might be an efficient means encapsulating, protecting delivering hydrophobic bioactive compounds for applications functional foods.